Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity

Abstract Obesity, a multifactorial disorder, results from a chronic imbalance of energy intake vs. expenditure. Apart from excessive consumption of high calorie diet, genetic predisposition also seems to be equally important for the development of obesity. However, the role of genetic predisposition...

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Main Authors: Muralidhar MN, Prasad SMVK, Kiran Kumar Battula, Giridharan NV, Rajender Rao Kalashikam
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-09149-6
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spelling doaj-facebc07e19a453c87d182ddca7bb4da2020-12-08T02:23:06ZengNature Publishing GroupScientific Reports2045-23222017-08-017111210.1038/s41598-017-09149-6Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesityMuralidhar MN0Prasad SMVK1Kiran Kumar Battula2Giridharan NV3Rajender Rao Kalashikam4Laboratory of Molecular Genetics, National Centre for Laboratory Animal Sciences, National Institute of NutritionLaboratory of Molecular Genetics, National Centre for Laboratory Animal Sciences, National Institute of NutritionLaboratory of Molecular Genetics, National Centre for Laboratory Animal Sciences, National Institute of NutritionLaboratory of Molecular Genetics, National Centre for Laboratory Animal Sciences, National Institute of NutritionLaboratory of Molecular Genetics, National Centre for Laboratory Animal Sciences, National Institute of NutritionAbstract Obesity, a multifactorial disorder, results from a chronic imbalance of energy intake vs. expenditure. Apart from excessive consumption of high calorie diet, genetic predisposition also seems to be equally important for the development of obesity. However, the role of genetic predisposition in the etiology of obesity has not been clearly delineated. The present study addresses this problem by selecting three rat strains (WNIN, F-344, SD) with different genetic backgrounds and exposing them to high calorie diets. Rat strains were fed HF, HS, and HFS diets and assessed for physical, metabolic, biochemical, inflammatory responses, and mRNA expression. Under these conditions: significant increase in body weight, visceral adiposity, oxidative stress and systemic pro-inflammatory status; the hallmarks of central obesity were noticed only in WNIN. Further, they developed altered glucose and lipid homeostasis by exhibiting insulin resistance, impaired glucose tolerance, dyslipidemia and fatty liver condition. The present study demonstrates that WNIN is more prone to develop obesity and associated co-morbidities under high calorie environment. It thus underlines the cumulative role of genetics (nature) and diet (nurture) towards the development of obesity, which is critical for understanding this epidemic and devising new strategies to control and manage this modern malady.https://doi.org/10.1038/s41598-017-09149-6
collection DOAJ
language English
format Article
sources DOAJ
author Muralidhar MN
Prasad SMVK
Kiran Kumar Battula
Giridharan NV
Rajender Rao Kalashikam
spellingShingle Muralidhar MN
Prasad SMVK
Kiran Kumar Battula
Giridharan NV
Rajender Rao Kalashikam
Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity
Scientific Reports
author_facet Muralidhar MN
Prasad SMVK
Kiran Kumar Battula
Giridharan NV
Rajender Rao Kalashikam
author_sort Muralidhar MN
title Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity
title_short Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity
title_full Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity
title_fullStr Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity
title_full_unstemmed Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity
title_sort differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity
publisher Nature Publishing Group
series Scientific Reports
issn 2045-2322
publishDate 2017-08-01
description Abstract Obesity, a multifactorial disorder, results from a chronic imbalance of energy intake vs. expenditure. Apart from excessive consumption of high calorie diet, genetic predisposition also seems to be equally important for the development of obesity. However, the role of genetic predisposition in the etiology of obesity has not been clearly delineated. The present study addresses this problem by selecting three rat strains (WNIN, F-344, SD) with different genetic backgrounds and exposing them to high calorie diets. Rat strains were fed HF, HS, and HFS diets and assessed for physical, metabolic, biochemical, inflammatory responses, and mRNA expression. Under these conditions: significant increase in body weight, visceral adiposity, oxidative stress and systemic pro-inflammatory status; the hallmarks of central obesity were noticed only in WNIN. Further, they developed altered glucose and lipid homeostasis by exhibiting insulin resistance, impaired glucose tolerance, dyslipidemia and fatty liver condition. The present study demonstrates that WNIN is more prone to develop obesity and associated co-morbidities under high calorie environment. It thus underlines the cumulative role of genetics (nature) and diet (nurture) towards the development of obesity, which is critical for understanding this epidemic and devising new strategies to control and manage this modern malady.
url https://doi.org/10.1038/s41598-017-09149-6
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