Krüppel-like Factor 4 Modulates Development of BMI1+ Intestinal Stem Cell-Derived Lineage Following γ-Radiation-Induced Gut Injury in Mice

Krüppel-like Factor 4 Modulates Development of BMI1+ Intestinal Stem Cell-Derived Lineage Following γ-Radiation-Induced Gut Injury in Mice

Summary: In response to ionizing radiation-induced injury, the normally quiescent intestinal stem cells marked by BMI1 participate in the regenerative response. Previously, we established a protective role for Krüppel-like factor 4 (KLF4) in the intestinal epithelium where it reduces senescence, apo...

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Bibliographic Details
Main Authors: Jes G. Kuruvilla, Chang-Kyung Kim, Amr M. Ghaleb, Agnieszka B. Bialkowska, Calvin J. Kuo, Vincent W. Yang
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221367111630039X

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http://www.sciencedirect.com/science/article/pii/S221367111630039X

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