Somatic mutation analysis of <it>MYH11 </it>in breast and prostate cancer
<p>Abstract</p> <p>Background</p> <p><it>MYH11 </it>(also known as <it>SMMHC</it>) encodes the smooth-muscle myosin heavy chain, which has a key role in smooth muscle contraction. Inversion at the <it>MYH11 </it>locus is one of the mo...
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doaj-fab7bf30ea9f4e0880d362e009df816c2020-11-24T21:39:30ZengBMCBMC Cancer1471-24072008-09-018126310.1186/1471-2407-8-263Somatic mutation analysis of <it>MYH11 </it>in breast and prostate cancerWaltering KatiWinqvist RobertKarhu AuliAlhopuro PiaVisakorpi TapioAaltonen Lauri A<p>Abstract</p> <p>Background</p> <p><it>MYH11 </it>(also known as <it>SMMHC</it>) encodes the smooth-muscle myosin heavy chain, which has a key role in smooth muscle contraction. Inversion at the <it>MYH11 </it>locus is one of the most frequent chromosomal aberrations found in acute myeloid leukemia. We have previously shown that <it>MYH11 </it>mutations occur in human colorectal cancer, and may also be associated with Peutz-Jeghers syndrome. The mutations found in human intestinal neoplasia result in unregulated proteins with constitutive motor activity, similar to the mutant <it>myh11 </it>underlying the zebrafish <it>meltdown </it>phenotype characterized by disrupted intestinal architecture. Recently, <it>MYH1 </it>and <it>MYH9 </it>have been identified as candidate breast cancer genes in a systematic analysis of the breast cancer genome.</p> <p>Methods</p> <p>The aim of this study was to investigate the role of somatic <it>MYH11 </it>mutations in two common tumor types; breast and prostate cancers. A total of 155 breast cancer and 71 prostate cancer samples were analyzed for those regions in <it>MYH11 </it>(altogether 8 exons out of 42 coding exons) that harboured mutations in colorectal cancer in our previous study.</p> <p>Results</p> <p>In breast cancer samples only germline alterations were observed. One prostate cancer sample harbored a frameshift mutation c.5798delC, which we have previously shown to result in a protein with unregulated motor activity.</p> <p>Conclusion</p> <p>Little evidence for a role of somatic <it>MYH11 </it>mutations in the formation of breast or prostate cancers was obtained in this study.</p> http://www.biomedcentral.com/1471-2407/8/263 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Waltering Kati Winqvist Robert Karhu Auli Alhopuro Pia Visakorpi Tapio Aaltonen Lauri A |
spellingShingle |
Waltering Kati Winqvist Robert Karhu Auli Alhopuro Pia Visakorpi Tapio Aaltonen Lauri A Somatic mutation analysis of <it>MYH11 </it>in breast and prostate cancer BMC Cancer |
author_facet |
Waltering Kati Winqvist Robert Karhu Auli Alhopuro Pia Visakorpi Tapio Aaltonen Lauri A |
author_sort |
Waltering Kati |
title |
Somatic mutation analysis of <it>MYH11 </it>in breast and prostate cancer |
title_short |
Somatic mutation analysis of <it>MYH11 </it>in breast and prostate cancer |
title_full |
Somatic mutation analysis of <it>MYH11 </it>in breast and prostate cancer |
title_fullStr |
Somatic mutation analysis of <it>MYH11 </it>in breast and prostate cancer |
title_full_unstemmed |
Somatic mutation analysis of <it>MYH11 </it>in breast and prostate cancer |
title_sort |
somatic mutation analysis of <it>myh11 </it>in breast and prostate cancer |
publisher |
BMC |
series |
BMC Cancer |
issn |
1471-2407 |
publishDate |
2008-09-01 |
description |
<p>Abstract</p> <p>Background</p> <p><it>MYH11 </it>(also known as <it>SMMHC</it>) encodes the smooth-muscle myosin heavy chain, which has a key role in smooth muscle contraction. Inversion at the <it>MYH11 </it>locus is one of the most frequent chromosomal aberrations found in acute myeloid leukemia. We have previously shown that <it>MYH11 </it>mutations occur in human colorectal cancer, and may also be associated with Peutz-Jeghers syndrome. The mutations found in human intestinal neoplasia result in unregulated proteins with constitutive motor activity, similar to the mutant <it>myh11 </it>underlying the zebrafish <it>meltdown </it>phenotype characterized by disrupted intestinal architecture. Recently, <it>MYH1 </it>and <it>MYH9 </it>have been identified as candidate breast cancer genes in a systematic analysis of the breast cancer genome.</p> <p>Methods</p> <p>The aim of this study was to investigate the role of somatic <it>MYH11 </it>mutations in two common tumor types; breast and prostate cancers. A total of 155 breast cancer and 71 prostate cancer samples were analyzed for those regions in <it>MYH11 </it>(altogether 8 exons out of 42 coding exons) that harboured mutations in colorectal cancer in our previous study.</p> <p>Results</p> <p>In breast cancer samples only germline alterations were observed. One prostate cancer sample harbored a frameshift mutation c.5798delC, which we have previously shown to result in a protein with unregulated motor activity.</p> <p>Conclusion</p> <p>Little evidence for a role of somatic <it>MYH11 </it>mutations in the formation of breast or prostate cancers was obtained in this study.</p> |
url |
http://www.biomedcentral.com/1471-2407/8/263 |
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