A New Application of the Hill Repressor Function: Automatic Control of a Conic Tank Level and Local Stability Analysis

The Hill function is commonly used as a building block to model different dynamic patterns found in the response of genetic regulatory circuits within microorganisms and cells. These circuits are characterized by fast response and robustness against unmeasured disturbances. Therefore, microorganisms...

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Main Authors: José Ricardo Pérez-Correa, Gastón Lefranc, Mario Fernández-Fernández
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Mathematical Problems in Engineering
Online Access:http://dx.doi.org/10.1155/2015/271216
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spelling doaj-fab58b1362a04e3b9a598d165609e75f2020-11-25T01:20:39ZengHindawi LimitedMathematical Problems in Engineering1024-123X1563-51472015-01-01201510.1155/2015/271216271216A New Application of the Hill Repressor Function: Automatic Control of a Conic Tank Level and Local Stability AnalysisJosé Ricardo Pérez-Correa0Gastón Lefranc1Mario Fernández-Fernández2Departamento de Ingeniería Química y Bioprocesos, Pontificia Universidad Católica de Chile, Avenida Vicuña Mackenna 4860, 7820436 Santiago, ChileEscuela de Ingeniería Eléctrica, Pontificia Universidad Católica De Valparaíso, Avenida Brasil 2950, 2340000 Valparaíso, ChileDepartamento de Tecnologías Industriales, Universidad de Talca, Camino a Los Niches km 1, 3440000 Curicó, ChileThe Hill function is commonly used as a building block to model different dynamic patterns found in the response of genetic regulatory circuits within microorganisms and cells. These circuits are characterized by fast response and robustness against unmeasured disturbances. Therefore, microorganisms and cells can survive even if they are subjected to strong changes in their environment. However, as far as we know, the Hill function has not been used before to design process control systems. In this work, the repressor Hill function is applied to control the level of a conic tank. To eliminate the offset, we added integrative action. A local analysis was applied to define stability limits for the control parameters. A cost function that includes the error and the control effort was used to compare the performance of the Hill control against a standard PI and a PID-Dahlin controller.http://dx.doi.org/10.1155/2015/271216
collection DOAJ
language English
format Article
sources DOAJ
author José Ricardo Pérez-Correa
Gastón Lefranc
Mario Fernández-Fernández
spellingShingle José Ricardo Pérez-Correa
Gastón Lefranc
Mario Fernández-Fernández
A New Application of the Hill Repressor Function: Automatic Control of a Conic Tank Level and Local Stability Analysis
Mathematical Problems in Engineering
author_facet José Ricardo Pérez-Correa
Gastón Lefranc
Mario Fernández-Fernández
author_sort José Ricardo Pérez-Correa
title A New Application of the Hill Repressor Function: Automatic Control of a Conic Tank Level and Local Stability Analysis
title_short A New Application of the Hill Repressor Function: Automatic Control of a Conic Tank Level and Local Stability Analysis
title_full A New Application of the Hill Repressor Function: Automatic Control of a Conic Tank Level and Local Stability Analysis
title_fullStr A New Application of the Hill Repressor Function: Automatic Control of a Conic Tank Level and Local Stability Analysis
title_full_unstemmed A New Application of the Hill Repressor Function: Automatic Control of a Conic Tank Level and Local Stability Analysis
title_sort new application of the hill repressor function: automatic control of a conic tank level and local stability analysis
publisher Hindawi Limited
series Mathematical Problems in Engineering
issn 1024-123X
1563-5147
publishDate 2015-01-01
description The Hill function is commonly used as a building block to model different dynamic patterns found in the response of genetic regulatory circuits within microorganisms and cells. These circuits are characterized by fast response and robustness against unmeasured disturbances. Therefore, microorganisms and cells can survive even if they are subjected to strong changes in their environment. However, as far as we know, the Hill function has not been used before to design process control systems. In this work, the repressor Hill function is applied to control the level of a conic tank. To eliminate the offset, we added integrative action. A local analysis was applied to define stability limits for the control parameters. A cost function that includes the error and the control effort was used to compare the performance of the Hill control against a standard PI and a PID-Dahlin controller.
url http://dx.doi.org/10.1155/2015/271216
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