Targeted mutation of the gene encoding prion protein in zebrafish reveals a conserved role in neuron excitability

Targeted mutation of the gene encoding prion protein in zebrafish reveals a conserved role in neuron excitability

The function of the cellular prion protein (PrPC) in healthy brains remains poorly understood, in part because Prnp knockout mice are viable. On the other hand, transient knockdown of Prnp homologs in zebrafish (including two paralogs, prp1 and prp2) has suggested that PrPC is required for CNS devel...

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Bibliographic Details
Main Authors: Valerie C. Fleisch, Patricia L.A. Leighton, Hao Wang, Laura M. Pillay, R. Gary Ritzel, Ganive Bhinder, Birbickram Roy, Keith B. Tierney, Declan W. Ali, Andrew J. Waskiewicz, W. Ted Allison
Format: Article
Language:English
Published: Elsevier 2013-07-01
Series:Neurobiology of Disease
Subjects:
NMDA receptor
Prion protein
Seizure susceptibility
Targeted mutagenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113000958

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http://www.sciencedirect.com/science/article/pii/S0969996113000958

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