Inhibition of HIF-1α Reduced Blood Brain Barrier Damage by Regulating MMP-2 and VEGF During Acute Cerebral Ischemia

Inhibition of HIF-1α Reduced Blood Brain Barrier Damage by Regulating MMP-2 and VEGF During Acute Cerebral Ischemia

Increase of blood brain barrier (BBB) permeability after acute ischemia stroke is a predictor to intracerebral hemorrhage transformation (HT) for tissue plasminogen activator (tPA) thrombolysis and post-endovascular treatment. Previous studies showed that 2-h ischemia induced damage of BBB integrity...

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Bibliographic Details
Main Authors:	Yufei Shen, Jingxia Gu, Ziyun Liu, Congying Xu, Shuxia Qian, Xiaoling Zhang, Beiqun Zhou, Qiaobing Guan, Yanyun Sun, Yanping Wang, Xinchun Jin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-09-01
Series:	Frontiers in Cellular Neuroscience
Subjects:	blood brain barrier HIF-1α ischemia stroke matrix metalloproteinase vascular endothelial growth factor
Online Access:	https://www.frontiersin.org/article/10.3389/fncel.2018.00288/full

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