Inhibition of HIF-1α Reduced Blood Brain Barrier Damage by Regulating MMP-2 and VEGF During Acute Cerebral Ischemia

Inhibition of HIF-1α Reduced Blood Brain Barrier Damage by Regulating MMP-2 and VEGF During Acute Cerebral Ischemia

Increase of blood brain barrier (BBB) permeability after acute ischemia stroke is a predictor to intracerebral hemorrhage transformation (HT) for tissue plasminogen activator (tPA) thrombolysis and post-endovascular treatment. Previous studies showed that 2-h ischemia induced damage of BBB integrity...

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Bibliographic Details
Main Authors: Yufei Shen, Jingxia Gu, Ziyun Liu, Congying Xu, Shuxia Qian, Xiaoling Zhang, Beiqun Zhou, Qiaobing Guan, Yanyun Sun, Yanping Wang, Xinchun Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
blood brain barrier
HIF-1α
ischemia stroke
matrix metalloproteinase
vascular endothelial growth factor
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00288/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00288/full

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