RANK/RANKL/OPG LIGAND-RECEPTOR SYSTEM AND ITS ROLE IN PRIMARY BONE NEOPLASMS (LITERATURE ANALYSIS AND OWN DATA)

RANK/RANKL/OPG LIGAND-RECEPTOR SYSTEM AND ITS ROLE IN PRIMARY BONE NEOPLASMS (LITERATURE ANALYSIS AND OWN DATA)

RANK/RANKL/OPG ligand-receptor system is a key player in bone homeostasis regulation directly regulating osteoclast differentiation and osteolysis. Disbalance of bone homeostasis associated with malfunctioning of RANK/RANKL/OPG system underlies such oncological processes as the destruction of bone,...

Full description

Bibliographic Details
Main Authors: E. S. Gershtein, Yu. S. Timofeev, A. A. Zuev, N. E. Kushlinskii
Format: Article
Language:Russian
Published: ABV-press 2015-12-01
Series:Uspehi Molekulârnoj Onkologii
Subjects:
receptor activator of nf-κb (rank)
rank ligand (rankl)
osteoprotegerin
bone sarcomas
giant-cell bone tumor
targeted therapy
denosumab
blood serum
Online Access:https://umo.abvpress.ru/jour/article/view/45

Similar Items

Similar Items