Anti-Inflammatory Effects of the Novel PIM Kinase Inhibitor KMU‐470 in RAW 264.7 Cells Through the TLR4‐NF‐κB‐NLRP3 Pathway

Anti-Inflammatory Effects of the Novel PIM Kinase Inhibitor KMU‐470 in RAW 264.7 Cells Through the TLR4‐NF‐κB‐NLRP3 Pathway

PIM kinases, a small family of serine/threonine kinases, are important intermediates in the cytokine signaling pathway of inflammatory disease. In this study, we investigated whether the novel PIM kinase inhibitor KMU-470, a derivative of indolin-2-one, inhibits lipopolysaccharide (LPS)-induced infl...

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Bibliographic Details
Main Authors: Hye Suk Baek, Hyeon Ji Min, Victor Sukbong Hong, Taeg Kyu Kwon, Jong Wook Park, Jinho Lee, Shin Kim
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
KMU-470
PIM kinase
TLR4
LPS
inflammation
NF‐κB
Online Access:https://www.mdpi.com/1422-0067/21/14/5138

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