Detection of drug resistant Mycobacterium tuberculosis by high-throughput sequencing of DNA isolated from acid fast bacilli smears.

Detection of drug resistant Mycobacterium tuberculosis by high-throughput sequencing of DNA isolated from acid fast bacilli smears.

<h4>Background</h4>Drug susceptibility testing for Mycobacterium tuberculosis (MTB) is difficult to perform in resource-limited settings where Acid Fast Bacilli (AFB) smears are commonly used for disease diagnosis and monitoring. We developed a simple method for extraction of MTB DNA fro...

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Bibliographic Details
Main Authors: Mazhgan Rowneki, Naomi Aronson, Peicheng Du, Paige Sachs, Robert Blakemore, Soumitesh Chakravorty, Shawn Levy, Angela L Jones, Geetika Trivedi, Sheilla Chebore, Dennis Addo, Denis K Byarugaba, Panganani Dalisani Njobvu, Frederick Wabwire-Mangen, Bernard Erima, Eric S Ramos, Carlton A Evans, Braden Hale, James D Mancuso, David Alland
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0232343

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