Assessment of serum cytokines, stress hormones and oxidative stress indexes after tubeless PCNL treatment of upper ureteral calculi

• Main Author: Ming-Cheng Zhang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-05-01
• Series: Journal of Hainan Medical University
• Subjects: Upper ureteral calculi T u b e l e s s p e r c u t a n e o u s nephrolithotomy Inflammatory factor Stress hormone Oxidative stress
• Online Access: http://www.hnykdxxb.com/PDF/201710/16.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To explore the effect of tubeless percutaneous nephrolithotomy (PCNL) treatment of upper ureteral calculi on serum cytokines, stress hormones and oxidative stress indexes. Methods: A total of 118 patients with upper ureteral calculi who were treated in our hospital between May 2014 and May 2016 were divided into the tubeless group (n=59) who received tubeless percutaneous nephrolithotomy and the tube-indwelling group (n=59) who received nephrostomy tube-indwelling percutaneous nephrolithotomy according to the random number table. The surgical success rate and stone residual rate of the two groups of patients were evaluated, and serum levels of inflammatory factors, stress hormones and oxidation/antioxidation indexes were determined. Results: Differences in surgical success rate and stone residual rate were not statistically significant between two groups of patients. 24 h after operation, serum inflammatory factors PCT, CRP, IL-1β and IL-6 levels of tubeless group were lower than those of tube-indwelling group, serum stress hormone Cor and NE levels were lower than those of tube-indwelling group, serum anti-oxidation indexes CAT and GSH-Px levels were higher than those of tube-indwelling group, and oxidation indexes MDA and ROS levels were lower than those of tube-indwelling group. Conclusion: Tubeless percutaneous nephrolithotomy treatment of upper ureteral calculi has similar curative effect to nephrostomy tube-indwelling percutaneous nephrolithotomy, but causes less surgical trauma, and is an ideal operation method.