Heart insufficiency after combination of verapamil and metoprolol: A fatal case report and literature review

Heart insufficiency after combination of verapamil and metoprolol: A fatal case report and literature review

Abstract The combination of verapamil or diltiazem with beta‐blockers should be avoided because of potentially profound adverse effects on AV (atrioventricular) nodal conduction, heart rate, or cardiac contractility. This effect is unpredictable but may be enhanced due to CYP2D6 poor metabolizer sta...

Full description

Bibliographic Details
Main Authors: Eva A. Saedder, Asser Hedegård Thomsen, Jørgen Bo Hasselstrøm, Jakob Ross Jornil
Format: Article
Language:English
Published: Wiley 2019-11-01
Series:Clinical Case Reports
Subjects:
cardiac insufficiency
cardiovascular toxicology
CYP2D6
drug‐drug interaction
metoprolol
verapamil
Online Access:https://doi.org/10.1002/ccr3.2393
Description
Summary:Abstract The combination of verapamil or diltiazem with beta‐blockers should be avoided because of potentially profound adverse effects on AV (atrioventricular) nodal conduction, heart rate, or cardiac contractility. This effect is unpredictable but may be enhanced due to CYP2D6 poor metabolizer status which could be a special vulnerability factor.
ISSN:2050-0904

Similar Items