MicroRNAs Targeting HIF-2α, VEGFR1 and/or VEGFR2 as Potential Predictive Biomarkers for VEGFR Tyrosine Kinase and HIF-2α Inhibitors in Metastatic Clear-Cell Renal Cell Carcinoma

MicroRNAs Targeting HIF-2α, VEGFR1 and/or VEGFR2 as Potential Predictive Biomarkers for VEGFR Tyrosine Kinase and HIF-2α Inhibitors in Metastatic Clear-Cell Renal Cell Carcinoma

Metastatic clear-cell renal cell carcinoma (m-ccRCC) is characterized by increased hypoxia-induced factor (HIF)-2α and vascular endothelial growth factor receptor (VEGFR)-dependent angiogenesis through loss of function of the von Hippel–Lindau protein. VEGFR tyrosine kinase inhibitors (VEGFR-TKIs) a...

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Bibliographic Details
Main Authors: Lisa Kinget, Eduard Roussel, Annelies Verbiest, Maarten Albersen, Cristina Rodríguez-Antona, Osvaldo Graña-Castro, Lucía Inglada-Pérez, Jessica Zucman-Rossi, Gabrielle Couchy, Sylvie Job, Aurélien de Reyniès, Annouschka Laenen, Marcella Baldewijns, Benoit Beuselinck
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
microRNAs
HIF-2α
VEGFR2
renal cell carcinoma
miR-34c-5p
miR-185-5p
Online Access:https://www.mdpi.com/2072-6694/13/12/3099

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