miR-203 Inhibits Frizzled-2 Expression via CD82/KAI1 Expression in Human Lung Carcinoma Cells.

CD82/KAI1, a member of the tetraspanin superfamily, is a suppressor of metastasis and CD82 inhibits canonical Wnt signaling via downregulation of several Frizzled (FZD) isoforms, resulting in accumulation of β-catenin at the cell membrane. In this study, we investigated the mechanism through which C...

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Bibliographic Details
Main Authors: Mariko Mine, Kojiro Yamaguchi, Tsuyoshi Sugiura, Satomi Chigita, Naoya Yoshihama, Rumi Yoshihama, Naomi Hiyake, Yosuke Kobayashi, Yoshihide Mori
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4488846?pdf=render