Metformin Strongly Affects Gut Microbiome Composition in High-Fat Diet-Induced Type 2 Diabetes Mouse Model of Both Sexes

Metformin Strongly Affects Gut Microbiome Composition in High-Fat Diet-Induced Type 2 Diabetes Mouse Model of Both Sexes

Effects of metformin, the first-line drug for type 2 diabetes therapy, on gut microbiome composition in type 2 diabetes have been described in various studies both in human subjects and animals. However, the details of the molecular mechanisms of metformin action have not been fully understood. More...

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Bibliographic Details
Main Authors: Laila Silamiķele, Ivars Silamiķelis, Monta Ustinova, Zane Kalniņa, Ilze Elbere, Ramona Petrovska, Ineta Kalniņa, Jānis Kloviņš
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Endocrinology
Subjects:
metformin
microbiome
metagenome
high-fat diet
C57BL/6N
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.626359/full

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