Antibiotics may increase triazine herbicide exposure risk via disturbing gut microbiota

Abstract Background Antibiotics are commonly used worldwide, and pesticide is a kind of xenobiotic to which humans are frequently exposed. The interactive impact of antibiotics on pesticides has rarely been studied. We aim to investigate the effects of antibiotics on the pesticide exposure risk and...

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Main Authors: Jing Zhan, Yiran Liang, Donghui Liu, Xiaoran Ma, Peize Li, Chang Liu, Xueke Liu, Peng Wang, Zhiqiang Zhou
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Microbiome
Subjects:
Online Access:http://link.springer.com/article/10.1186/s40168-018-0602-5
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spelling doaj-fa639bbf5a404e1f8bbeb3022baabfea2020-11-25T01:43:43ZengBMCMicrobiome2049-26182018-12-016111310.1186/s40168-018-0602-5Antibiotics may increase triazine herbicide exposure risk via disturbing gut microbiotaJing Zhan0Yiran Liang1Donghui Liu2Xiaoran Ma3Peize Li4Chang Liu5Xueke Liu6Peng Wang7Zhiqiang Zhou8Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Science, China Agricultural UniversityBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Science, China Agricultural UniversityBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Science, China Agricultural UniversityBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Science, China Agricultural UniversityBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Science, China Agricultural UniversityBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Science, China Agricultural UniversityBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Science, China Agricultural UniversityBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Science, China Agricultural UniversityBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Science, China Agricultural UniversityAbstract Background Antibiotics are commonly used worldwide, and pesticide is a kind of xenobiotic to which humans are frequently exposed. The interactive impact of antibiotics on pesticides has rarely been studied. We aim to investigate the effects of antibiotics on the pesticide exposure risk and whether gut microbiota altered by antibiotics has an influence on pesticide bioavailability. Furthermore, we explored the mechanisms of gut microbiota affecting the fate of pesticides in the host. Results The oral bioavailability of triazine herbicides significantly increased in the rats treated with ampicillin or antibiotic cocktails. The antibiotic-altered gut microbiota directly influenced the increased pesticide bioavailability through downregulating hepatic metabolic enzyme gene expression and upregulating intestinal absorption-related proteins. Conclusions Antibiotics could increase the pesticide bioavailability and thereby may increase the pesticide exposure risk. The antibiotic-altered gut microbiota that could alter the hepatic metabolic enzyme gene expression and intestinal absorption-related proteome was a critical cause of the increased bioavailability. This study revealed an undiscovered potential health impact of antibiotics and reminded people to consider the co-exposed xenobiotics when taking antibiotics.http://link.springer.com/article/10.1186/s40168-018-0602-5AntibioticsPesticide exposureGut microbiotaBioavailability
collection DOAJ
language English
format Article
sources DOAJ
author Jing Zhan
Yiran Liang
Donghui Liu
Xiaoran Ma
Peize Li
Chang Liu
Xueke Liu
Peng Wang
Zhiqiang Zhou
spellingShingle Jing Zhan
Yiran Liang
Donghui Liu
Xiaoran Ma
Peize Li
Chang Liu
Xueke Liu
Peng Wang
Zhiqiang Zhou
Antibiotics may increase triazine herbicide exposure risk via disturbing gut microbiota
Microbiome
Antibiotics
Pesticide exposure
Gut microbiota
Bioavailability
author_facet Jing Zhan
Yiran Liang
Donghui Liu
Xiaoran Ma
Peize Li
Chang Liu
Xueke Liu
Peng Wang
Zhiqiang Zhou
author_sort Jing Zhan
title Antibiotics may increase triazine herbicide exposure risk via disturbing gut microbiota
title_short Antibiotics may increase triazine herbicide exposure risk via disturbing gut microbiota
title_full Antibiotics may increase triazine herbicide exposure risk via disturbing gut microbiota
title_fullStr Antibiotics may increase triazine herbicide exposure risk via disturbing gut microbiota
title_full_unstemmed Antibiotics may increase triazine herbicide exposure risk via disturbing gut microbiota
title_sort antibiotics may increase triazine herbicide exposure risk via disturbing gut microbiota
publisher BMC
series Microbiome
issn 2049-2618
publishDate 2018-12-01
description Abstract Background Antibiotics are commonly used worldwide, and pesticide is a kind of xenobiotic to which humans are frequently exposed. The interactive impact of antibiotics on pesticides has rarely been studied. We aim to investigate the effects of antibiotics on the pesticide exposure risk and whether gut microbiota altered by antibiotics has an influence on pesticide bioavailability. Furthermore, we explored the mechanisms of gut microbiota affecting the fate of pesticides in the host. Results The oral bioavailability of triazine herbicides significantly increased in the rats treated with ampicillin or antibiotic cocktails. The antibiotic-altered gut microbiota directly influenced the increased pesticide bioavailability through downregulating hepatic metabolic enzyme gene expression and upregulating intestinal absorption-related proteins. Conclusions Antibiotics could increase the pesticide bioavailability and thereby may increase the pesticide exposure risk. The antibiotic-altered gut microbiota that could alter the hepatic metabolic enzyme gene expression and intestinal absorption-related proteome was a critical cause of the increased bioavailability. This study revealed an undiscovered potential health impact of antibiotics and reminded people to consider the co-exposed xenobiotics when taking antibiotics.
topic Antibiotics
Pesticide exposure
Gut microbiota
Bioavailability
url http://link.springer.com/article/10.1186/s40168-018-0602-5
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