CCCTC-Binding Factor Locks Premature IgH Germline Transcription and Restrains Class Switch Recombination

CCCTC-Binding Factor Locks Premature IgH Germline Transcription and Restrains Class Switch Recombination

In response to antigenic stimulation B cells undergo class switch recombination (CSR) at the immunoglobulin heavy chain (IgH) to replace the primary IgM/IgD isotypes by IgG, IgE, or IgA. CSR is initiated by activation-induced cytidine deaminase (AID) through the deamination of cytosine residues at t...

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Bibliographic Details
Main Authors: Ester Marina-Zárate, Arantxa Pérez-García, Almudena R. Ramiro
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Immunology
Subjects:
class switch recombination
CCCTC-binding factor
germline transcription
activation-induced deaminase
somatic hypermutation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01076/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01076/full

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