Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver Failure

Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver Failure

Brain edema in acute liver failure (ALF) remains lethal. Cytotoxic mechanisms associated with brain edema have been well recognized, but the role of vasogenic mechanisms of brain edema has not been explored. Intact tight junctions (TJs) between brain capillary endothelial cells are critical for norm...

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Main Authors: Wei Cui, Cui-Ming Sun, Pei Liu
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Gastroenterology Research and Practice
Online Access:http://dx.doi.org/10.1155/2013/841707
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spelling doaj-fa5e2ae5b9ad4f9ab8ae7cf8c9df31962020-11-24T22:36:21ZengHindawi LimitedGastroenterology Research and Practice1687-61211687-630X2013-01-01201310.1155/2013/841707841707Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver FailureWei Cui0Cui-Ming Sun1Pei Liu2Department of Infectious Diseases, The First Affiliated Hospital, China Medical University, Shenyang 110001, ChinaDepartment of Infectious Diseases, The First Affiliated Hospital, China Medical University, Shenyang 110001, ChinaDepartment of Infectious Diseases, The First Affiliated Hospital, China Medical University, Shenyang 110001, ChinaBrain edema in acute liver failure (ALF) remains lethal. Cytotoxic mechanisms associated with brain edema have been well recognized, but the role of vasogenic mechanisms of brain edema has not been explored. Intact tight junctions (TJs) between brain capillary endothelial cells are critical for normal BBB function. Recent reports found significant alterations in the tight junction elements including occludin and claudin-5, suggesting a vasogenic injury in the blood-brain barrier (BBB) integrity. However, the role of TJ in ALF has not been completely understood. This paper reviews the role of the paracellular tight junction in the increased selective BBB permeability that leads to brain edema in ALF and furthermore explores the effect of systemic inflammatory cytokines on the tight junction dysfunction.http://dx.doi.org/10.1155/2013/841707
collection DOAJ
language English
format Article
sources DOAJ
author Wei Cui
Cui-Ming Sun
Pei Liu
spellingShingle Wei Cui
Cui-Ming Sun
Pei Liu
Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver Failure
Gastroenterology Research and Practice
author_facet Wei Cui
Cui-Ming Sun
Pei Liu
author_sort Wei Cui
title Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver Failure
title_short Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver Failure
title_full Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver Failure
title_fullStr Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver Failure
title_full_unstemmed Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver Failure
title_sort alterations of blood-brain barrier and associated factors in acute liver failure
publisher Hindawi Limited
series Gastroenterology Research and Practice
issn 1687-6121
1687-630X
publishDate 2013-01-01
description Brain edema in acute liver failure (ALF) remains lethal. Cytotoxic mechanisms associated with brain edema have been well recognized, but the role of vasogenic mechanisms of brain edema has not been explored. Intact tight junctions (TJs) between brain capillary endothelial cells are critical for normal BBB function. Recent reports found significant alterations in the tight junction elements including occludin and claudin-5, suggesting a vasogenic injury in the blood-brain barrier (BBB) integrity. However, the role of TJ in ALF has not been completely understood. This paper reviews the role of the paracellular tight junction in the increased selective BBB permeability that leads to brain edema in ALF and furthermore explores the effect of systemic inflammatory cytokines on the tight junction dysfunction.
url http://dx.doi.org/10.1155/2013/841707
work_keys_str_mv AT weicui alterationsofbloodbrainbarrierandassociatedfactorsinacuteliverfailure
AT cuimingsun alterationsofbloodbrainbarrierandassociatedfactorsinacuteliverfailure
AT peiliu alterationsofbloodbrainbarrierandassociatedfactorsinacuteliverfailure
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