Embelin Restores Carbapenem Efficacy against NDM-1-Positive Pathogens

Embelin Restores Carbapenem Efficacy against NDM-1-Positive Pathogens

The emergence and spread of carbapenemase in Gram-negative pathogens poses an enormous threat to global public health. New Delhi metallo-β-lactamase-1 (NDM-1) inactivates nearly every class of β-lactam antibiotics, including carbapenem; however, there is no clinically useful NDM-1 inhibitor. Embelin...

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Bibliographic Details
Main Authors: Nian-Zhi Ning, Xiong Liu, Fanghong Chen, Peng Zhou, Lihong Hu, Jian Huang, Zhan Li, Jie Huang, Tao Li, Hui Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Microbiology
Subjects:
embelin
carbapenem
NDM-1
carbapenemase
inhibitor
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00071/full

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