Stimulation of Erythrocyte Cell Membrane Scrambling by Mitotane

Stimulation of Erythrocyte Cell Membrane Scrambling by Mitotane

Background: Mitotane (1,1-dichloro-2-[o-chlorophenyl]-2-[p-chlorophenyl]ethane), a cytostatic drug used for the treatment of adrenocortical carcinomas, is effective by triggering tumor cell apoptosis. In analogy to apoptosis of nucleated cells, eryptosis is the suicidal death of erythrocytes, which...

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Bibliographic Details
Main Authors: Janin Jacobi, Elisabeth Lang, Rosi Bissinger, Leonie Frauenfeld, Paola Modicano, Caterina Faggio, Majed Abed, Florian Lang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Phosphatidylserine
Ionomycin
Calcium
Eryptosis
Cell volume
Online Access:http://www.karger.com/Article/FullText/358715

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