"PREDICTIVE SIGNIFICANCE OF SERUM INTERLEUKIN-10 FOR ACUTE GRAFT VERSUS HOST DISEASE PRIOR TO ALLOGENEIC BONE MARROW TRASPLANTATION "

"PREDICTIVE SIGNIFICANCE OF SERUM INTERLEUKIN-10 FOR ACUTE GRAFT VERSUS HOST DISEASE PRIOR TO ALLOGENEIC BONE MARROW TRASPLANTATION "

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Interleukin-10 (IL-10) is a potent immunosuppressor which inhibits alloantigenic T cell response. IL-10 is also an anti-inflammatory endogenous cytokine. To investigate the predictive significance of endogenous IL-10 for acute graft versus host disease (GVHD) following allogeneic bone marrow transpl...

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Bibliographic Details
Main Authors: M. Iravani, B. Mohebbi, B. Bahar, K. Alimoghadam, A. Moosavi, S. Najar-Najafi, A. Ardalan A. Ghavamzadeh
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2005-06-01
Series:Acta Medica Iranica
Subjects:
interleukin-10
graft versus host disease
Online Access:https://acta.tums.ac.ir/index.php/acta/article/view/2988
Description
Summary:Interleukin-10 (IL-10) is a potent immunosuppressor which inhibits alloantigenic T cell response. IL-10 is also an anti-inflammatory endogenous cytokine. To investigate the predictive significance of endogenous IL-10 for acute graft versus host disease (GVHD) following allogeneic bone marrow transplantation (BMT), we performed a prospective study on spontaneous IL-10 production in the serum of 96 patients admitted for allogeneic BMT. High spontaneous IL-10 production at the time of admission and prior to any preparative treatment correlates with a subsequent low incidence of GVHD as compared to patients with low IL-10 production. Our data demonstrate the predictive significance of increased IL-10 production in BMT patients and suggest a role for it in maintaining immunobalance in the setting of allogenic BMT.
ISSN:0044-6025
1735-9694

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