| Summary: | Aim: Neuroblastoma accounts for approximately %10
of all pediatric cancers and approximately %15 of cancer related deaths in
children. Understanding of the molecular mechanisms which play role in the
progress of this cancer type may lead to develop more effective strategies for
therapy. Flavanoids are popular subject for this new strategies. Hesperidin is an
herbal flavonoid which is found abundantly in citrus that has been studied on
several cancer cell lines. For this purpose, it was aimed to investigate is the
apoptotic effects of hesperidin on neuroblastoma tumors using SH-SY5Y cell line.Methods: Hesperidin
was performed on SH-SY5Y and MRC-5 cell line by WST-1, Caspase-3 and
Annexin V in a time and dose dependent manner. Results: 2.5 µM hesperidin and 5 µM hesperidin were
found the most suitable dosage for neuroblastoma cell line because of the
success on decreasing cell proliferation. Hesperidin has resulted with the
ability for apoptotic cell death compared with control group [MRC-5 cell line,
p<0.05 for all]. 2,5 µM and 5 µM hesperidin concentration for 48h were ended
up early apoptotic results as 53.65% for 2.5 µM and 38.90% for 5 µM. There was
no significant change on caspase-3 activity.
Conclusions: Our study suggests that hesperidin would be effective
against neuroblastoma tumors. We believe with further investigation this study
will be helpful for developing new research areas in neuroblastoma tumors.
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