Small molecule R1498 as a well-tolerated and orally active kinase inhibitor for hepatocellular carcinoma and gastric cancer treatment via targeting angiogenesis and mitosis pathways.

Small molecule R1498 as a well-tolerated and orally active kinase inhibitor for hepatocellular carcinoma and gastric cancer treatment via targeting angiogenesis and mitosis pathways.

Protein kinases play important roles in tumor development and progression. Lots of kinase inhibitors have entered into market and show promising clinical benefits. Here we report the discovery of a novel small molecule, well-tolerated, orally active kinase inhibitor, R1498, majorly targeting both an...

Full description

Bibliographic Details
Main Authors: Chao Zhang, Xihan Wu, Meifang Zhang, Liangcheng Zhu, Rong Zhao, Danqing Xu, Zhaohu Lin, Chungen Liang, Taiping Chen, Li Chen, Yi Ren, Joe Zhang, Ning Qin, Xiongwen Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3673949?pdf=render

Internet

http://europepmc.org/articles/PMC3673949?pdf=render

Similar Items