Estimation of Prophylactic Efficacy of the Grippol® Vaccine for Large-Scale Immunization in Adult and Children's Organized Collectives in the Republic of Belarus

• Main Authors: N. P. Shmeleva, V. P. Shimanovich, N. V. Sivets, T. P. Lapo, N. V. Gribkova
• Format: Article
• Language: Russian
• Published: Numikom LLC 2017-10-01
• Series: Эпидемиология и вакцинопрофилактика
• Subjects: грипп; орви; вакцинация; организованные коллективы; взрослые; школьники; заболеваемость; influenza; acute respiratory infection; organized collectives; adults; schoolchildren; morbidity
• Online Access: https://www.epidemvac.ru/jour/article/view/318
• ISSN: 2073-3046; 2619-0494

Abstract estimation of anti-epidemic efficacy of a polymer-subunit vaccine Grippol® for large-scale immunization in adult work collectives and secondary schools in Vitebsk, Minsk and Grodno was conducted. Acute respiratory infection agents were detected by the means of RT-PCR in selected individuals. The overall number of participants was 12308 (5391 were children aged 6 - 17 and 6917 were 18 years or older). Influenza and ARI morbidity analysis demonstrates that Grippol® plus has a high anti-epidemic efficacy, reducing the influenza morbidity in the vaccinated cohort by 2.1 (adults) and 3.0 (children) times compared to that in unvaccinated persons. Efficacy and efficacy rate amounted to 50 3% and 2 2 in adults and 66 2% and 3 0 in children respectively A decrease in number of recurrent diseases complications in children was also demonstrated A dynamic morbidity analysis showed that in unvaccinated children there had been an evident increase in influenza and ARI among the unvaccinated children in late January - February 2016, while among the children who were vaccinated the morbidity rate was consistently low across all months of the influenza season.