Genomic responses during acute human anaphylaxis are characterized by upregulation of innate inflammatory gene networks.

Genomic responses during acute human anaphylaxis are characterized by upregulation of innate inflammatory gene networks.

BACKGROUND: Systemic spread of immune activation and mediator release is required for the development of anaphylaxis in humans. We hypothesized that peripheral blood leukocyte (PBL) activation plays a key role. OBJECTIVE: To characterize PBL genomic responses during acute anaphylaxis. METHODS: PBL s...

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Bibliographic Details
Main Authors: Shelley F Stone, Anthony Bosco, Anya Jones, Claire L Cotterell, Pauline E van Eeden, Glenn Arendts, Daniel M Fatovich, Simon G A Brown
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4077795?pdf=render

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