Biomechanical Forces Regulate Gene Transcription During Stretch-Mediated Growth of Mammalian Neurons

At birth, there are 100 billion neurons in the human brain, with functional neural circuits extending through the spine to the epidermis of the feet and toes. Following birth, limbs and vertebrae continue to grow by several orders of magnitude, forcing established axons to grow by up to 200 cm in le...

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Bibliographic Details
Main Authors: Joseph R. Loverde, Rosa E. Tolentino, Patricia Soteropoulos, Bryan J. Pfister
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2020.600136/full