PER1 rs3027172 genotype interacts with early life stress to predict problematic alcohol use, but not reward-related ventral striatum activity

PER1 rs3027172 genotype interacts with early life stress to predict problematic alcohol use, but not reward-related ventral striatum activity

Increasing evidence suggests that the circadian and stress regulatory systems contribute to alcohol use disorder (AUD) risk, which may partially arise through effects on reward-related neural function. The C allele of the PER1 rs3027172 single nucleotide polymorphism reduces PER1 expression in cells...

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Bibliographic Details
Main Authors: David eBaranger, Chloe eIfrah, Aric A Prather, Caitlin E Carey, Nadia S Corral-Frias, Emily D Conley, Ahmad R Hariri, Ryan eBogdan
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Psychology
Subjects:
stress
alcohol
circadian
ventral striatum
early life stress
GxE
Online Access:http://journal.frontiersin.org/Journal/10.3389/fpsyg.2016.00464/full

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