Anti-Interleukin-6 Promotes Allogeneic Bone Marrow Engraftment and Prolonged Graft Survival in an Irradiation-Free Murine Transplant Model

Anti-Interleukin-6 Promotes Allogeneic Bone Marrow Engraftment and Prolonged Graft Survival in an Irradiation-Free Murine Transplant Model

Transfer of recipient regulatory T cells (Tregs) induces mixed chimerism and tolerance in an irradiation-free bone marrow (BM) transplantation (BMT) model involving short-course co-stimulation blockade and mTOR inhibition. Boosting endogenous Tregs pharmacologically in vivo would be an attractive al...

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Bibliographic Details
Main Authors: Nicolas Granofszky, Andreas M. Farkas, Moritz Muckenhuber, Benedikt Mahr, Lukas Unger, Svenja Maschke, Nina Pilat, Raimund Holly, Mario Wiletel, Heinz Regele, Thomas Wekerle
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Immunology
Subjects:
transplantation
tolerance
chimerism
interleukin-6
regulatory T cells
bone marrow transplantation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00821/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00821/full

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