Nuclear GRP75 binds retinoic acid receptors to promote neuronal differentiation of neuroblastoma.

Retinoic acid (RA) has been approved for the differentiation therapy of neuroblastoma (NB). Previous work revealed a correlation between glucose-regulated protein 75 (GRP75) and the RA-elicited neuronal differentiation of NB cells. The present study further demonstrated that GRP75 translocates into...

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Main Authors: Yu-Yin Shih, Hsinyu Lee, Akira Nakagawara, Hseuh-Fen Juan, Yung-Ming Jeng, Yeou-Guang Tsay, Dong-Tsamn Lin, Fon-Jou Hsieh, Chien-Yuan Pan, Wen-Ming Hsu, Yung-Feng Liao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3194821?pdf=render