Frequency of CYP2D6 Alleles Including Structural Variants in the United States

Frequency of CYP2D6 Alleles Including Structural Variants in the United States

The CYP2D6 gene encodes an enzyme important in the metabolism of many commonly used medications. Variation in CYP2D6 is associated with inter-individual differences in medication response, and genetic testing is used to optimize medication therapy. This report describes a retrospective study of CYP2...

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Bibliographic Details
Main Authors: Andria L. Del Tredici, Alka Malhotra, Matthew Dedek, Frank Espin, Dan Roach, Guang-dan Zhu, Joseph Voland, Tanya A. Moreno
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Pharmacology
Subjects:
CYP2D6
pharmacogenetics
drug metabolism
copy number variation
cytochrome P450
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00305/full

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