Scale-up of micro- and milli-reactors: An overview of strategies, design principles and applications

Scale-up of micro- and milli-reactors: An overview of strategies, design principles and applications

Continuous-flow microreactor technology has been embraced by researchers in academia and industry due to its excellent transport properties and the increased safety and control over challenging chemical transformations. Despite its popularity, scaling the benefits associated with the microenvironmen...

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Bibliographic Details
Main Authors: Zhengya Dong, Zhenghui Wen, Fang Zhao, Simon Kuhn, Timothy Noël
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Chemical Engineering Science: X
Subjects:
Scale up
Numbering up
Sizing up
Microreactor
Millireactor
Flow Chemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S2590140021000101
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spelling doaj-f9e2be7a3cb946b8b50e0aec977bfd992021-05-14T04:19:54ZengElsevierChemical Engineering Science: X2590-14002021-05-0110100097Scale-up of micro- and milli-reactors: An overview of strategies, design principles and applicationsZhengya Dong0Zhenghui Wen1Fang Zhao2Simon Kuhn3Timothy Noël4Micro Flow Chemistry and Synthetic Methodology, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Het Kranenveld, Bldg 14 – Helix, 5600 MB Eindhoven, the NetherlandsMicro Flow Chemistry and Synthetic Methodology, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Het Kranenveld, Bldg 14 – Helix, 5600 MB Eindhoven, the NetherlandsMicro Flow Chemistry and Synthetic Methodology, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Het Kranenveld, Bldg 14 – Helix, 5600 MB Eindhoven, the NetherlandsKU Leuven, Department of Chemical Engineering, Celestijnenlaan 200F, 3001 Leuven, BelgiumMicro Flow Chemistry and Synthetic Methodology, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Het Kranenveld, Bldg 14 – Helix, 5600 MB Eindhoven, the NetherlandsContinuous-flow microreactor technology has been embraced by researchers in academia and industry due to its excellent transport properties and the increased safety and control over challenging chemical transformations. Despite its popularity, scaling the benefits associated with the microenvironment has proven to be a daunting challenge. This review provides an up-to-date overview concerning the different scale-up approaches of micro/milli-reactors, including numbering up (both internal and external), sizing up (increasing length, geometry similarity and constant pressure drop strategies) and a combination of numbering up and sizing up. The strategies, design principles and applications of each approach have been discussed in detail. Each scale-up approach has its merits and limitations. However, scale-up factors, that are required in the fine chemical and pharmaceutical industry, are within reach when different scale-up approaches are combined.http://www.sciencedirect.com/science/article/pii/S2590140021000101Scale upNumbering upSizing upMicroreactorMillireactorFlow Chemistry
collection DOAJ
language English
format Article
sources DOAJ
author Zhengya Dong
Zhenghui Wen
Fang Zhao
Simon Kuhn
Timothy Noël
spellingShingle Zhengya Dong
Zhenghui Wen
Fang Zhao
Simon Kuhn
Timothy Noël
Scale-up of micro- and milli-reactors: An overview of strategies, design principles and applications
Chemical Engineering Science: X
Scale up
Numbering up
Sizing up
Microreactor
Millireactor
Flow Chemistry
author_facet Zhengya Dong
Zhenghui Wen
Fang Zhao
Simon Kuhn
Timothy Noël
author_sort Zhengya Dong
title Scale-up of micro- and milli-reactors: An overview of strategies, design principles and applications
title_short Scale-up of micro- and milli-reactors: An overview of strategies, design principles and applications
title_full Scale-up of micro- and milli-reactors: An overview of strategies, design principles and applications
title_fullStr Scale-up of micro- and milli-reactors: An overview of strategies, design principles and applications
title_full_unstemmed Scale-up of micro- and milli-reactors: An overview of strategies, design principles and applications
title_sort scale-up of micro- and milli-reactors: an overview of strategies, design principles and applications
publisher Elsevier
series Chemical Engineering Science: X
issn 2590-1400
publishDate 2021-05-01
description Continuous-flow microreactor technology has been embraced by researchers in academia and industry due to its excellent transport properties and the increased safety and control over challenging chemical transformations. Despite its popularity, scaling the benefits associated with the microenvironment has proven to be a daunting challenge. This review provides an up-to-date overview concerning the different scale-up approaches of micro/milli-reactors, including numbering up (both internal and external), sizing up (increasing length, geometry similarity and constant pressure drop strategies) and a combination of numbering up and sizing up. The strategies, design principles and applications of each approach have been discussed in detail. Each scale-up approach has its merits and limitations. However, scale-up factors, that are required in the fine chemical and pharmaceutical industry, are within reach when different scale-up approaches are combined.
topic Scale up
Numbering up
Sizing up
Microreactor
Millireactor
Flow Chemistry
url http://www.sciencedirect.com/science/article/pii/S2590140021000101
work_keys_str_mv AT zhengyadong scaleupofmicroandmillireactorsanoverviewofstrategiesdesignprinciplesandapplications
AT zhenghuiwen scaleupofmicroandmillireactorsanoverviewofstrategiesdesignprinciplesandapplications
AT fangzhao scaleupofmicroandmillireactorsanoverviewofstrategiesdesignprinciplesandapplications
AT simonkuhn scaleupofmicroandmillireactorsanoverviewofstrategiesdesignprinciplesandapplications
AT timothynoel scaleupofmicroandmillireactorsanoverviewofstrategiesdesignprinciplesandapplications
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