Emerging mechanisms of valproic acid-induced neurotoxic events in autism and its implications for pharmacological treatment

Emerging mechanisms of valproic acid-induced neurotoxic events in autism and its implications for pharmacological treatment

Autism spectrum disorder (ASD) is a sort of mental disorder marked by deficits in cognitive and communication abilities. To date no effective cure for this pernicious disease has been available. Valproic acid (VPA) is a broad-spectrum, antiepileptic drug, and it is also a potent teratogen. Epidemiol...

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Bibliographic Details
Main Authors: Abdoh Taleb, Wen Lin, Xiang Xu, Gang Zhang, Qi-Gang Zhou, Muhammad Naveed, Fan Meng, Kohji Fukunaga, Feng Han
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Valproic acid
Autism spectrum disorder
Neuroinflammation
Synaptic transmission
Pharmacological therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221001074

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