Interleukin-2-Inducible T-Cell Kinase Deficiency Impairs Early Pulmonary Protection Against Mycobacterium tuberculosis Infection

Interleukin-2-Inducible T-Cell Kinase Deficiency Impairs Early Pulmonary Protection Against Mycobacterium tuberculosis Infection

Interleukin-2 (IL-2) inducible T-cell kinase (ITK) is a non-receptor tyrosine kinase highly expressed in T-cell lineages and regulates multiple aspects of T-cell development and function, mainly through its function downstream of the T-cell receptor. Itk deficiency can lead to CD4 lymphopenia and Ep...

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Bibliographic Details
Main Authors: Lu Huang, Kaixiong Ye, Michael C. McGee, Natalie F. Nidetz, Jessica P. Elmore, Candice B. Limper, Teresa L. Southard, David G. Russell, Avery August, Weishan Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
active tuberculosis
transcriptomic analysis
non-receptor tyrosine kinase
IL-17A
IFN-γ
γδ T cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03103/full

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