p21<sup>WAF1 </sup>expression induced by MEK/ERK pathway activation or inhibition correlates with growth arrest, myogenic differentiation and onco-phenotype reversal in rhabdomyosarcoma cells

p21<sup>WAF1 </sup>expression induced by MEK/ERK pathway activation or inhibition correlates with growth arrest, myogenic differentiation and onco-phenotype reversal in rhabdomyosarcoma cells

<p>Abstract</p> <p>Background</p> <p>p21<sup>WAF1</sup>, implicated in the cell cycle control of both normal and malignant cells, can be induced by p53-dependent and independent mechanisms. In some cells, MEKs/ERKs regulate p21<sup>WAF1 </sup>tra...

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Bibliographic Details
Main Authors: Giacinti Cristina, Mauro Annunziata, Scoglio Arianna, Marampon Francesco, Ciccarelli Carmela, De Cesaris Paola, Zani Bianca M
Format: Article
Language:English
Published: BMC 2005-12-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/4/1/41

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