Transcriptional activation of muscle atrophy promotes cardiac muscle remodeling during mammalian hibernation

Transcriptional activation of muscle atrophy promotes cardiac muscle remodeling during mammalian hibernation

Background. Mammalian hibernation in thirteen-lined ground squirrels (Ictidomys tridecemlineatus) is characterized by dramatic changes on a physiological and molecular level. During hibernation, mammalian hearts show a propensity to hypertrophy due to the need for increasing contractility to pump co...

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Bibliographic Details
Main Authors: Yichi Zhang, Oscar A. Aguilar, Kenneth B. Storey
Format: Article
Language:English
Published: PeerJ Inc. 2016-08-01
Series:PeerJ
Subjects:
Ictidomys tridecemlineatus
Muscle remodelling
Foxo
Western blotting
MAFbx
Ubiquitin ligase
Online Access:https://peerj.com/articles/2317.pdf

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