Synthesis and Characterization of New Diketone Analogues of Podophyllotoxin

Synthesis and Characterization of New Diketone Analogues of Podophyllotoxin

The new compounds 6,6a-dihydro-2,3-dimethoxy-9-nitro–11bH benzo [C]-fluoren 5,7-dione, 6,6a-dihydro-2,3-dimethoxy-9-chloro–11bH benzo[C]-fluoren-5,7-dione and 6,6a-dihydro-2,3-dimethoxy-9-fluoro–11bH benzo[C]-fluoren-5,7- dione were synthesized in high yields. They are analogues of naturally occurri...

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Main Authors: K. H. Hemakumar, A. D. Sathisha, Y. B. Basavaraju
Format: Article
Language:English
Published: Hindawi Limited 2008-01-01
Series:E-Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2008/314724
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spelling doaj-f9be9ce380c64a609fb9b273abeeea142020-11-25T00:59:06ZengHindawi LimitedE-Journal of Chemistry0973-49452090-98102008-01-015111411910.1155/2008/314724Synthesis and Characterization of New Diketone Analogues of PodophyllotoxinK. H. Hemakumar0A. D. Sathisha1Y. B. Basavaraju2Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, IndiaDepartment of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, IndiaDepartment of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, IndiaThe new compounds 6,6a-dihydro-2,3-dimethoxy-9-nitro–11bH benzo [C]-fluoren 5,7-dione, 6,6a-dihydro-2,3-dimethoxy-9-chloro–11bH benzo[C]-fluoren-5,7-dione and 6,6a-dihydro-2,3-dimethoxy-9-fluoro–11bH benzo[C]-fluoren-5,7- dione were synthesized in high yields. They are analogues of naturally occurring lignan podophyllotoxin which exhibits anticancer activity. They are very essential to study anticancer activity.http://dx.doi.org/10.1155/2008/314724
collection DOAJ
language English
format Article
sources DOAJ
author K. H. Hemakumar
A. D. Sathisha
Y. B. Basavaraju
spellingShingle K. H. Hemakumar
A. D. Sathisha
Y. B. Basavaraju
Synthesis and Characterization of New Diketone Analogues of Podophyllotoxin
E-Journal of Chemistry
author_facet K. H. Hemakumar
A. D. Sathisha
Y. B. Basavaraju
author_sort K. H. Hemakumar
title Synthesis and Characterization of New Diketone Analogues of Podophyllotoxin
title_short Synthesis and Characterization of New Diketone Analogues of Podophyllotoxin
title_full Synthesis and Characterization of New Diketone Analogues of Podophyllotoxin
title_fullStr Synthesis and Characterization of New Diketone Analogues of Podophyllotoxin
title_full_unstemmed Synthesis and Characterization of New Diketone Analogues of Podophyllotoxin
title_sort synthesis and characterization of new diketone analogues of podophyllotoxin
publisher Hindawi Limited
series E-Journal of Chemistry
issn 0973-4945
2090-9810
publishDate 2008-01-01
description The new compounds 6,6a-dihydro-2,3-dimethoxy-9-nitro–11bH benzo [C]-fluoren 5,7-dione, 6,6a-dihydro-2,3-dimethoxy-9-chloro–11bH benzo[C]-fluoren-5,7-dione and 6,6a-dihydro-2,3-dimethoxy-9-fluoro–11bH benzo[C]-fluoren-5,7- dione were synthesized in high yields. They are analogues of naturally occurring lignan podophyllotoxin which exhibits anticancer activity. They are very essential to study anticancer activity.
url http://dx.doi.org/10.1155/2008/314724
work_keys_str_mv AT khhemakumar synthesisandcharacterizationofnewdiketoneanaloguesofpodophyllotoxin
AT adsathisha synthesisandcharacterizationofnewdiketoneanaloguesofpodophyllotoxin
AT ybbasavaraju synthesisandcharacterizationofnewdiketoneanaloguesofpodophyllotoxin
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