A comprehensive assessment of metabolic parameters in obese patients on xenical

• Main Authors: A S Ametov, T Yu Demidova, A L Tselikovskaya
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2004-01-01
• Series: Терапевтический архив
• Subjects: metabolic syndrome; fat tissue; hyperinsulinemia; xenical
• Online Access: https://ter-arkhiv.ru/0040-3660/article/view/29764

Aim. To study effects ofxenical combined with moderately hypocaloric diet on fat tissue mass, carbohydrate and lipid metabolism in patients with metabolic syndrome. Material and methods. The study included 60 patients with body mass index (BMI) over 30 kg/m2, mild and moderate arterial hypertension, dyslipidemia, impaired glucose tolerance (IGT) and diabetes mellitus (DM) type 2. The patients were divided into two groups. 30 patients of group 1 received xenicaf® in a dose 120 mg 3 times a day for 24 weeks. 30 patients of the control group received only the above diet for 24 weeks. The examination included 24-h monitoring of arterial pressure, anthropometric measurements, tests for glycemia, C-peptide, cholesterol, triglycerides (TG), LDLP, HDLP. Results. Group 1 patients reduced their weight by 10.8 + 7.5 kg and fat tissue mass by 9.4 ± 9.2 kg. This was in correlation with improvement of fatty, carbohydrate metabolism, arterial pressure. After 24 weeks of therapy xenical lowered cholesterol by 15%, LDLP cholesterol by 20%, TG by 28%, systolic and diastolic pressure by 5 and 4%. Conclusion. Combination ofxenical with hypocaloric diet can be used in therapy of patients with metabolic syndrome.