Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] Cycloaddition

Peculiarities of [8+2] cycloaddition of acetylenes to indolizines are reviewed. Especially mentioned are indolizines with leaving groups at positions 3 and 5. Cycloaddition to aza- and benzo derivatives are reviewed, as well as 1,10-cyclizations and processes leading to cyclazines where indolizines...

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Main Authors:	Eugene V. Babaev, Ivan A. Shadrin
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Series:	Molecules
Subjects:	indolizine azaindolizines benzoindolizines cyclazine [8+2] cycloaddition mechanism
Online Access:	https://www.mdpi.com/1420-3049/26/7/2050

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spelling	doaj-f9b2ebdc73e941af8adc943c41ccd7b72021-04-03T23:00:11ZengMDPI AGMolecules1420-30492021-04-01262050205010.3390/molecules26072050Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] CycloadditionEugene V. Babaev0Ivan A. Shadrin1Chemistry Department, Moscow State University, Leninskie gory, 1 str. 3, 119899 Moscow, RussiaChemistry Department, Moscow State University, Leninskie gory, 1 str. 3, 119899 Moscow, RussiaPeculiarities of [8+2] cycloaddition of acetylenes to indolizines are reviewed. Especially mentioned are indolizines with leaving groups at positions 3 and 5. Cycloaddition to aza- and benzo derivatives are reviewed, as well as 1,10-cyclizations and processes leading to cyclazines where indolizines are intermediates. Mechanistic features (adducts and cycloadducts) and theoretical aspects (one- or two-steps mechanism) are reviewed.https://www.mdpi.com/1420-3049/26/7/2050indolizineazaindolizinesbenzoindolizinescyclazine[8+2] cycloadditionmechanism
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Eugene V. Babaev Ivan A. Shadrin
spellingShingle	Eugene V. Babaev Ivan A. Shadrin Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] Cycloaddition Molecules indolizine azaindolizines benzoindolizines cyclazine [8+2] cycloaddition mechanism
author_facet	Eugene V. Babaev Ivan A. Shadrin
author_sort	Eugene V. Babaev
title	Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] Cycloaddition
title_short	Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] Cycloaddition
title_full	Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] Cycloaddition
title_fullStr	Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] Cycloaddition
title_full_unstemmed	Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] Cycloaddition
title_sort	indolizines and their hetero/benzo derivatives in reactions of [8+2] cycloaddition
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2021-04-01
description	Peculiarities of [8+2] cycloaddition of acetylenes to indolizines are reviewed. Especially mentioned are indolizines with leaving groups at positions 3 and 5. Cycloaddition to aza- and benzo derivatives are reviewed, as well as 1,10-cyclizations and processes leading to cyclazines where indolizines are intermediates. Mechanistic features (adducts and cycloadducts) and theoretical aspects (one- or two-steps mechanism) are reviewed.
topic	indolizine azaindolizines benzoindolizines cyclazine [8+2] cycloaddition mechanism
url	https://www.mdpi.com/1420-3049/26/7/2050
work_keys_str_mv	AT eugenevbabaev indolizinesandtheirheterobenzoderivativesinreactionsof82cycloaddition AT ivanashadrin indolizinesandtheirheterobenzoderivativesinreactionsof82cycloaddition
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Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] Cycloaddition

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