Potential Metabolite Nymphayol Isolated from Water Lily (<i>Nymphaea stellata</i>) Flower Inhibits MCF-7 Human Breast Cancer Cell Growth via Upregulation of Cdkn2a, pRb2, p53 and Downregulation of PCNA mRNA Expressions

Potential Metabolite Nymphayol Isolated from Water Lily (<i>Nymphaea stellata</i>) Flower Inhibits MCF-7 Human Breast Cancer Cell Growth via Upregulation of Cdkn2a, pRb2, p53 and Downregulation of PCNA mRNA Expressions

Controlled production of cyclin dependent kinases (CDK) and stabilization of tumor suppressor genes are the most important factors involved in preventing carcinogenesis. The present study aimed to explore the cyclin dependent apoptotic effect of nymphayol on breast cancer MCF-7 cells. In our previou...

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Bibliographic Details
Main Authors: Laila Naif Al-Harbi, Pandurangan Subash-Babu, Manal Abdulaziz Binobead, Maha Hussain Alhussain, Sahar Abdulaziz AlSedairy, Amal A Aloud, Ali A Alshatwi
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Metabolites
Subjects:
<i>Nymphaea stellata</i>
MCF-7 cells
cytotoxicity
tumor suppressor gene
apoptosis
Online Access:https://www.mdpi.com/2218-1989/10/7/280

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