LasR Variant Cystic Fibrosis Isolates Reveal an Adaptable Quorum-Sensing Hierarchy in Pseudomonas aeruginosa

LasR Variant Cystic Fibrosis Isolates Reveal an Adaptable Quorum-Sensing Hierarchy in Pseudomonas aeruginosa

Chronic Pseudomonas aeruginosa infections cause significant morbidity in patients with cystic fibrosis (CF). Over years to decades, P. aeruginosa adapts genetically as it establishes chronic lung infections. Nonsynonymous mutations in lasR, the quorum-sensing (QS) master regulator, are common in CF....

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Main Authors: John B. Feltner, Daniel J. Wolter, Christopher E. Pope, Marie-Christine Groleau, Nicole E. Smalley, E. Peter Greenberg, Nicole Mayer-Hamblett, Jane Burns, Eric Déziel, Lucas R. Hoffman, Ajai A. Dandekar
Format: Article
Language:English
Published: American Society for Microbiology 2016-10-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/7/5/e01513-16

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