FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ.

FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ.

Nimustine (ACNU) and temozolomide (TMZ) are DNA alkylating agents which are commonly used in chemotherapy for glioblastomas. ACNU is a DNA cross-linking agent and TMZ is a methylating agent. The therapeutic efficacy of these agents is limited by the development of resistance. In this work, the role...

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Bibliographic Details
Main Authors: Natsuko Kondo, Akihisa Takahashi, Eiichiro Mori, Taichi Noda, Małgorzata Z Zdzienicka, Larry H Thompson, Thomas Helleday, Minoru Suzuki, Yuko Kinashi, Shinichiro Masunaga, Koji Ono, Masatoshi Hasegawa, Takeo Ohnishi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3090409?pdf=render

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