Microwave-assisted synthesis of biologically relevant steroidal 17-exo-pyrazol-5'-ones from a norpregnene precursor by a side-chain elongation/heterocyclization sequence

Microwave-assisted synthesis of biologically relevant steroidal 17-exo-pyrazol-5'-ones from a norpregnene precursor by a side-chain elongation/heterocyclization sequence

Multistep syntheses of novel 17β-pyrazol-5'-ones in the Δ5-androstane series were efficiently carried out from pregnenolone acetate. A steroidal 17-carboxylic acid was first synthesized as a norpregnene precursor by the bromoform reaction and subsequent acetylation. Its CDI-activated acylimidaz...

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Bibliographic Details
Main Authors: Gergő Mótyán, László Mérai, Márton Attila Kiss, Zsuzsanna Schelz, Izabella Sinka, István Zupkó, Éva Frank
Format: Article
Language:English
Published: Beilstein-Institut 2018-10-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
antiproliferative activity
Knorr reaction
microwave
pyrazol-5-ones
steroids
Online Access:https://doi.org/10.3762/bjoc.14.236

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