Is it a supplementary benefit to use anti-inflammatory agents in the treatment of type 2 diabetes?

• Main Authors: Nzogang K. Patrice, Donkeng J. Martial, Telefo P. Bruno
• Format: Article
• Language: English
• Published: BMC 2017-09-01
• Series: BMC Research Notes
• Subjects: Type 2 diabetes; Inflammation; hs-CRP; Glycated haemoglobin and arterial pressure
• Online Access: http://link.springer.com/article/10.1186/s13104-017-2785-4
• ISSN: 1756-0500

Abstract Objective The aim of this study was to investigate an independent correlation between high sensitivity C-reactive protein (hs-CRP) and glycated haemoglobin (HbA1c) on one side and between hs-CRP and arterial pressure in well glucose controlled type 2 diabetics on the other side. Results The mean of HbA1c was 6.37% in this study and 70.10% of participants had an HbA1c less than 7%. A positive correlation between hs-CRP and HbA1c was found in the current study (r = 0.232; P = 0.043) and we observed a decrease of 0.79% of HbA1c of the participants when their hs-CRP was less than 1 mg/l compared to that of the participants who had hs-CRP more than 1 mg/l (5.75 ± 1.25% VS 6.54 ± 1.42% P value = 0.04 Student). No correlation was found between hs-CRP and arterial pressure in this study. These results could justify the perspective use of anti-inflammatory drugs in the management of T2D. However the presence of participants with HbA1c levels greater than 7% makes plausible the influence of confounding factors on the observed correlations.