Influence of OASL gene polymorphisms on host response to interferon therapy in chronic hepatitis C virus patients

Hepatitis C virus (HCV) infection becomes a major public health problem and leading cause of chronic liver disease and liver failure. Pegylated interferon-alfa and ribavirin are currently the standard treatment for chronic hepatitis C (CHC). It is indicated that genes that trace the interferon signa...

Full description

Bibliographic Details
Main Authors: Kiprijanovska Sanja, Stefanovska Emilija Sukarova, Noveski Predrag, Ivanova Viktorija Chaloska, Plaseska-Karanfilska Dijana
Format: Article
Language:English
Published: Sciendo 2017-05-01
Series:The EuroBiotech Journal
Online Access:https://doi.org/10.24190/ISSN2564-615X/2017/02.02
id doaj-f99b4f7673af4f42b38144b2040f7d5b
record_format Article
spelling doaj-f99b4f7673af4f42b38144b2040f7d5b2021-09-05T17:19:35ZengSciendoThe EuroBiotech Journal2564-615X2017-05-011211712510.24190/ISSN2564-615X/2017/02.02Influence of OASL gene polymorphisms on host response to interferon therapy in chronic hepatitis C virus patientsKiprijanovska Sanja0Stefanovska Emilija Sukarova1Noveski Predrag2Ivanova Viktorija Chaloska3Plaseska-Karanfilska Dijana4Research Center for Genetic Engineering and Biotechnology “Georgi D. Efremov”, Macedonian Academy of Sciences and Arts, Skopje, R. MacedoniaResearch Center for Genetic Engineering and Biotechnology “Georgi D. Efremov”, Macedonian Academy of Sciences and Arts, Skopje, R. MacedoniaResearch Center for Genetic Engineering and Biotechnology “Georgi D. Efremov”, Macedonian Academy of Sciences and Arts, Skopje, R. MacedoniaClinic of Gastroenterohepatology, Medical Faculty, Skopje, Republic of MacedoniaResearch Center for Genetic Engineering and Biotechnology “Georgi D. Efremov”, Macedonian Academy of Sciences and Arts, Skopje, R. MacedoniaHepatitis C virus (HCV) infection becomes a major public health problem and leading cause of chronic liver disease and liver failure. Pegylated interferon-alfa and ribavirin are currently the standard treatment for chronic hepatitis C (CHC). It is indicated that genes that trace the interferon signaling could be associated with the host response to the therapy. In order to investigate the influence of these genes on host related response, we have analyzed seven single nucleotide polymorphisms (rs59248852, rs74390571, rs12811390, rs1169279, rs3213545, rs1083129 and rs2859398) in 2-5-Oligoadenylate- Synthetase-Like (OASL) gene in CHC cases from Republic of Macedonia. A simple and easy to use SNaPshot method was developed. A cohort of 100 HCV RNA positive patients - non responders and 109 patients with achieved virological response after the standard treatment were included in this study. We have found significant association in five of the seven studied SNP` s: rs59248852 [p = 6.5x10-31, OR=55.7 (20.0-155.3)]; rs12811390 [p = 2.2x10-11, OR=4.3 (2.3-6.7)]; rs2859398 [p=1.34x10-9, OR=3.4 (2.2-5.0)]; rs74390571 [p=4.3x10-7, OR=2.9 (1.9-4.4)], and rs1083129 [p=0.0139, OR=2.0 (1.1-3.5)]. The results from this study can be used as a predictive factor of future patient’s selection for the standard therapy, having an important cost benefit for the health insurance system.https://doi.org/10.24190/ISSN2564-615X/2017/02.02
collection DOAJ
language English
format Article
sources DOAJ
author Kiprijanovska Sanja
Stefanovska Emilija Sukarova
Noveski Predrag
Ivanova Viktorija Chaloska
Plaseska-Karanfilska Dijana
spellingShingle Kiprijanovska Sanja
Stefanovska Emilija Sukarova
Noveski Predrag
Ivanova Viktorija Chaloska
Plaseska-Karanfilska Dijana
Influence of OASL gene polymorphisms on host response to interferon therapy in chronic hepatitis C virus patients
The EuroBiotech Journal
author_facet Kiprijanovska Sanja
Stefanovska Emilija Sukarova
Noveski Predrag
Ivanova Viktorija Chaloska
Plaseska-Karanfilska Dijana
author_sort Kiprijanovska Sanja
title Influence of OASL gene polymorphisms on host response to interferon therapy in chronic hepatitis C virus patients
title_short Influence of OASL gene polymorphisms on host response to interferon therapy in chronic hepatitis C virus patients
title_full Influence of OASL gene polymorphisms on host response to interferon therapy in chronic hepatitis C virus patients
title_fullStr Influence of OASL gene polymorphisms on host response to interferon therapy in chronic hepatitis C virus patients
title_full_unstemmed Influence of OASL gene polymorphisms on host response to interferon therapy in chronic hepatitis C virus patients
title_sort influence of oasl gene polymorphisms on host response to interferon therapy in chronic hepatitis c virus patients
publisher Sciendo
series The EuroBiotech Journal
issn 2564-615X
publishDate 2017-05-01
description Hepatitis C virus (HCV) infection becomes a major public health problem and leading cause of chronic liver disease and liver failure. Pegylated interferon-alfa and ribavirin are currently the standard treatment for chronic hepatitis C (CHC). It is indicated that genes that trace the interferon signaling could be associated with the host response to the therapy. In order to investigate the influence of these genes on host related response, we have analyzed seven single nucleotide polymorphisms (rs59248852, rs74390571, rs12811390, rs1169279, rs3213545, rs1083129 and rs2859398) in 2-5-Oligoadenylate- Synthetase-Like (OASL) gene in CHC cases from Republic of Macedonia. A simple and easy to use SNaPshot method was developed. A cohort of 100 HCV RNA positive patients - non responders and 109 patients with achieved virological response after the standard treatment were included in this study. We have found significant association in five of the seven studied SNP` s: rs59248852 [p = 6.5x10-31, OR=55.7 (20.0-155.3)]; rs12811390 [p = 2.2x10-11, OR=4.3 (2.3-6.7)]; rs2859398 [p=1.34x10-9, OR=3.4 (2.2-5.0)]; rs74390571 [p=4.3x10-7, OR=2.9 (1.9-4.4)], and rs1083129 [p=0.0139, OR=2.0 (1.1-3.5)]. The results from this study can be used as a predictive factor of future patient’s selection for the standard therapy, having an important cost benefit for the health insurance system.
url https://doi.org/10.24190/ISSN2564-615X/2017/02.02
work_keys_str_mv AT kiprijanovskasanja influenceofoaslgenepolymorphismsonhostresponsetointerferontherapyinchronichepatitiscviruspatients
AT stefanovskaemilijasukarova influenceofoaslgenepolymorphismsonhostresponsetointerferontherapyinchronichepatitiscviruspatients
AT noveskipredrag influenceofoaslgenepolymorphismsonhostresponsetointerferontherapyinchronichepatitiscviruspatients
AT ivanovaviktorijachaloska influenceofoaslgenepolymorphismsonhostresponsetointerferontherapyinchronichepatitiscviruspatients
AT plaseskakaranfilskadijana influenceofoaslgenepolymorphismsonhostresponsetointerferontherapyinchronichepatitiscviruspatients
_version_ 1717786670032486400