Deletion of β-Arrestin2 in Mice Limited Pancreatic β-Cell Expansion under Metabolic Stress through Activation of the JNK Pathway

Deletion of β-Arrestin2 in Mice Limited Pancreatic β-Cell Expansion under Metabolic Stress through Activation of the JNK Pathway

Abstract β-Arrestin2 (βarr2) is an adaptor protein that interacts with numerous signaling molecules and regulates insulin sensitivity. We reported previously that βarr2 was abundantly expressed in mouse pancreatic β-cells, and loss of βarr2 leads to impairment of acute- and late-phase insulin secret...

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Bibliographic Details
Main Authors: Ziwei Lin, Yu Zhao, Lige Song, Kaida Mu, Mingliang Zhang, Hongxia Liu, Xiaowen Li, Jian Zhao, Chen Wang, Weiping Jia
Format: Article
Language:English
Published: BMC 2016-02-01
Series:Molecular Medicine
Online Access:http://link.springer.com/article/10.2119/molmed.2015.00155

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