Berberine in the treatment of ulcerative colitis: A possible pathway through Tuft cells

Ulcerative colitis (UC) is an inflammatory bowel disease with complex pathogenesis, which is affected by genetic factors, intestinal immune status and intestinal microbial homeostasis. Intestinal epithelial barrier defect is crucial to the development of UC. Berberine, extracted from Chinese medicin...

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Main Authors:	Xinyu Xiong, Zhe Cheng, Fan Wu, Meilin Hu, Zhimin Liu, Ruolan Dong, Guang Chen
Format:	Article
Language:	English
Published:	Elsevier 2021-02-01
Series:	Biomedicine & Pharmacotherapy
Subjects:	Berberine Ulcerative colitis Bitter taste receptor Tuft cell Intestinal stem cell
Online Access:	http://www.sciencedirect.com/science/article/pii/S0753332220313226

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spelling	doaj-f997359a260644658a0f00426540666d2021-06-11T05:11:57ZengElsevierBiomedicine & Pharmacotherapy0753-33222021-02-01134111129Berberine in the treatment of ulcerative colitis: A possible pathway through Tuft cellsXinyu Xiong0Zhe Cheng1Fan Wu2Meilin Hu3Zhimin Liu4Ruolan Dong5Guang Chen6Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Coloproctology, The Sixth Affiliated Hospital of Sun Yat-sen University (Gastrointestinal & Anal Hospital of Sun Yat-sen University), Guangzhou 510655, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Corresponding author.Ulcerative colitis (UC) is an inflammatory bowel disease with complex pathogenesis, which is affected by genetic factors, intestinal immune status and intestinal microbial homeostasis. Intestinal epithelial barrier defect is crucial to the development of UC. Berberine, extracted from Chinese medicine, can identify bitter taste receptor on intestinal Tuft cells and activate IL-25-ILC2-IL-13 immune pathway to impair damaged intestinal tract by promoting differentiation of intestinal stem cells, which might be a potential approach for the treatment of UC.http://www.sciencedirect.com/science/article/pii/S0753332220313226BerberineUlcerative colitisBitter taste receptorTuft cellIntestinal stem cell
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xinyu Xiong Zhe Cheng Fan Wu Meilin Hu Zhimin Liu Ruolan Dong Guang Chen
spellingShingle	Xinyu Xiong Zhe Cheng Fan Wu Meilin Hu Zhimin Liu Ruolan Dong Guang Chen Berberine in the treatment of ulcerative colitis: A possible pathway through Tuft cells Biomedicine & Pharmacotherapy Berberine Ulcerative colitis Bitter taste receptor Tuft cell Intestinal stem cell
author_facet	Xinyu Xiong Zhe Cheng Fan Wu Meilin Hu Zhimin Liu Ruolan Dong Guang Chen
author_sort	Xinyu Xiong
title	Berberine in the treatment of ulcerative colitis: A possible pathway through Tuft cells
title_short	Berberine in the treatment of ulcerative colitis: A possible pathway through Tuft cells
title_full	Berberine in the treatment of ulcerative colitis: A possible pathway through Tuft cells
title_fullStr	Berberine in the treatment of ulcerative colitis: A possible pathway through Tuft cells
title_full_unstemmed	Berberine in the treatment of ulcerative colitis: A possible pathway through Tuft cells
title_sort	berberine in the treatment of ulcerative colitis: a possible pathway through tuft cells
publisher	Elsevier
series	Biomedicine & Pharmacotherapy
issn	0753-3322
publishDate	2021-02-01
description	Ulcerative colitis (UC) is an inflammatory bowel disease with complex pathogenesis, which is affected by genetic factors, intestinal immune status and intestinal microbial homeostasis. Intestinal epithelial barrier defect is crucial to the development of UC. Berberine, extracted from Chinese medicine, can identify bitter taste receptor on intestinal Tuft cells and activate IL-25-ILC2-IL-13 immune pathway to impair damaged intestinal tract by promoting differentiation of intestinal stem cells, which might be a potential approach for the treatment of UC.
topic	Berberine Ulcerative colitis Bitter taste receptor Tuft cell Intestinal stem cell
url	http://www.sciencedirect.com/science/article/pii/S0753332220313226
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Berberine in the treatment of ulcerative colitis: A possible pathway through Tuft cells

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