Berberine in the treatment of ulcerative colitis: A possible pathway through Tuft cells

Berberine in the treatment of ulcerative colitis: A possible pathway through Tuft cells

Ulcerative colitis (UC) is an inflammatory bowel disease with complex pathogenesis, which is affected by genetic factors, intestinal immune status and intestinal microbial homeostasis. Intestinal epithelial barrier defect is crucial to the development of UC. Berberine, extracted from Chinese medicin...

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Bibliographic Details
Main Authors: Xinyu Xiong, Zhe Cheng, Fan Wu, Meilin Hu, Zhimin Liu, Ruolan Dong, Guang Chen
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Berberine
Ulcerative colitis
Bitter taste receptor
Tuft cell
Intestinal stem cell
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220313226
Description
Summary:Ulcerative colitis (UC) is an inflammatory bowel disease with complex pathogenesis, which is affected by genetic factors, intestinal immune status and intestinal microbial homeostasis. Intestinal epithelial barrier defect is crucial to the development of UC. Berberine, extracted from Chinese medicine, can identify bitter taste receptor on intestinal Tuft cells and activate IL-25-ILC2-IL-13 immune pathway to impair damaged intestinal tract by promoting differentiation of intestinal stem cells, which might be a potential approach for the treatment of UC.
ISSN:0753-3322

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