Comparing Acute and Chronic Effects of 1-(3-Chlorophenyl) Piperazine and Mianserin Injection on Yawning and Penile Erection in Rats

• Main Authors: M. Torkamani Noughabi, G.H. Vaezi, H. Abtahi Eivari, V. Hojati
• Format: Article
• Language: English
• Published: Gonabad University of Medical Sciences (GMU) 2018-09-01
• Series: Ufuq-i Dānish
• Subjects: Yawning [https://www.ncbi.nlm.nih.gov/mesh/68015000]; Penile Erection [https://www.ncbi.nlm.nih.gov/mesh/68010410]; Mianserin [https://www.ncbi.nlm.nih.gov/mesh/68008803]
• Online Access: http://hms.gmu.ac.ir/article-1-2795-en.pdf
• ISSN: 1735-1855; 2252-0805

Aims: Yawning is a phylogenetic and contagious behavior that occurs with the stretching or penile erection in mammals, birds, and reptiles under different conditions. This study aimed at determining the acute and chronic effects of the injection of 1-(3-chlorophenyl) Piperazine and Mianserin on yawning and penile erection of adult male rats. Materials and Methods: In this experimental study, 30 male Wistar rats (250-300g) were randomly divided to 3 groups (n=10), including the control group that received saline subcutaneous injection, the group that received 0.5mg/kg 1-(3-chlorophenyl) Piperazine subcutaneous injection, and the group that received 0.2mg/kg Mianserin subcutaneous injection. After the subcutaneous injections in acute phase (day1) and chronic phase (day14), the number of yawning and penile erection was observed for 60 minutes and it was recorded. The data were analyzed by SPSS 13 software using one-way analysis of variance, Tukey post-hoc, and paired t-test. Findings: Compared with the control group, Mianserin group showed a significant increase in the number of yawning (p<0.01) and penile erection (p<0.05) in the acute phase. Compared with the acute phase, the chronic group of Mianserin showed a significant decrease in the number of yawning (p<0.01) and penile erection (p<0.05). Compared with the acute group, 1-(3-Chlorophenyl) Piperazine showed a significant increase in the number of yawning (p<0.05) only in the chronic phase. Conclusion: The acute injection of Mianserin increases the number of yawning and penile erection of adult male rats and its chronic injection decreases them. 1-(3-Chlorophenyl) Piperazine increases the number of yawning only in the chronic phase.