PBRM1 loss in kidney cancer unbalances the proximal tubule master transcription factor hub to repress proximal tubule differentiation

PBRM1 loss in kidney cancer unbalances the proximal tubule master transcription factor hub to repress proximal tubule differentiation

Summary: PBRM1, a subunit of the PBAF coactivator complex that transcription factors use to activate target genes, is genetically inactivated in almost all clear cell renal cell cancers (RCCs). Using unbiased proteomic analyses, we find that PAX8, a master transcription factor driver of proximal tub...

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Bibliographic Details
Main Authors: Xiaorong Gu, Francis Enane, Rita Tohme, Caroline Schuerger, Tomas Radivoyevitch, Yvonne Parker, Eric Zuberi, Bartlomiej Przychodzen, Babal Kant Jha, Daniel Lindner, Brian Rini, Yogen Saunthararajah
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Cell Reports
Subjects:
renal cell cancer
PBRM1
PAX8
MYC
epithelial differentiation
coactivator
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721012018

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