Anaplastic Lymphoma Kinase positive large B cell lymphoma of ileocaecal mesentery: A case report

• Main Authors: Aravinth Subramaniam, Divya Gnanasekaran, Saravanakumar Suruliraj, Palanivelu Chinnusamy
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2020-01-01
• Series: Indian Journal of Pathology and Microbiology
• Subjects: anaplastic lymphoma kinase positive large b cell lymphoma; cltc-alk gene; dlbcl; mesentery
• Online Access: http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2020;volume=63;issue=4;spage=615;epage=617;aulast=Subramaniam

ALK+ large B cell lymphoma (LBCL) is a very rare aggressive neoplasm. It accounts for less than 1% of diffuse large B cell lymphoma (DLBCL). This is a case report of ALK+ DLBCL in a 34-year-old woman with an ileocaecal mesenteric mass. Microscopically, the neoplastic cells were of high grade along with a spindle cell component. Immunohistochemistry revealed ALK+, MUM-1+, LCA+, Vimentin+, EMA+ and negative for CK 20, CK 7, neuroendocrine, melanocytic, muscle specific, and GIST panel markers. This case report, hence, presents the rarity of this tumor.